For people who feel like they have tried everything

For the person who has been through the antidepressant list, the therapists, the supplements, and the advice, and is tired of being told to try the same things again. Masha speaks to anyone exhausted by the usual answers: people whose depression has not moved despite doing everything they were asked. The talk runs under a minute.

It sits on the treatment-resistant depression page and the ketamine therapy page because those are the two places tried-everything patients usually land. Resistant does not mean untreatable; it often means the standard sequence was the wrong fit. Spravato (esketamine), ketamine-assisted psychotherapy, and pharmacogenomic testing are the options that open once that is acknowledged, each with its own screening and its own limits. A 90-minute evaluation is where that acknowledgment starts.

This video is educational and is not medical advice.